Which Will Kill You First?

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The body can get a whole lot colder – but not a whole lot hotter – before we die. Why is that?

LEARN MORE
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To learn more about this topic, start your googling with these keywords:
Hyperthermia: a medical condition where an individual’s body temperature is elevated beyond normal
Hypothermia: a medical doncition that occurs when an individual’s body loses heat faster than it can produce heat, causing a dangerously low body temperature
Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different
Denaturation: the alteration of a protein shape through some form of external stress (for example, heat), so that it can no longer carry out its cellular function

If you liked this week’s video, you might also like:
A great article from Outside on hyperthermia: https://www.outsideonline.com/2398105/heat-stroke-signs-symptoms
Learn more about the woman who survived the lowest known body temp: https://www.atlasobscura.com/articles/the-woman-who-survived-the-lowest-body-temperature-ever

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CREDITS
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Kate Yoshida | Script Writer, Narrator and Director
Sarah Berman | Illustration, Video Editing and Animation
Nathaniel Schroeder | Music

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REFERENCES
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Lepock JR (2004). Role of nuclear protein denaturation and aggregation
in thermal radiosensitization, International Journal of Hyperthermia, 20:2, 115-130, https://www.tandfonline.com/doi/abs/10.1080/02656730310001637334

Leuenberger, P, Ganscha S, Kahraman A, Cappelletti V, PJ Boersema, Mering Cv, Claassen M, Picotti P (2017). Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability
Science, 355: eaai7825. https://science.sciencemag.org/content/355/6327/eaai7825

Roti Roti J (2008) Cellular responses to hyperthermia (40–46 degrees C): cell killing and molecular events. International Journal of Hyperthermia 24(1): 3–15. https://www.tandfonline.com/doi/full/10.1080/02656730701769841

Sawka MN, Leon LR, Montain SJ, Sonna LA (2011). Integrated physiological mechanisms of exercise performance, adaptation, and maladaptation to heat stress. Comprehensive Physiology 1: 1883-1928. https://onlinelibrary.wiley.com/doi/abs/10.1002/cphy.c100082

Slovis CM, Anderson GF, Casolaro A (1982). Survival in a heat stroke victim with a core temperature in excess of 46.5 C. Annals of Emergency Medicine 11(5):269-271. https://linkinghub.elsevier.com/retrieve/pii/S0196-0644(82)80099-1

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